Xopenex HFA
Levalbuterol Tartrate
CAS: 661464-94-4
Molecular Formula: C17H27NO9
Xopenex HFA - Names and Identifiers
| Name | Levalbuterol Tartrate |
| Synonyms | Xopenex HFA UNII-ADS4I3E22M Levalbuterol tartrate Levalbuterol Tartrate Levosalbutamol tartrate Levalbuterol tartrate [USP] Levalbuterol tartrate (Levosalbutamol tartrate) (R)-4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxy-methyl)phenol (2R,3R)-2,3-dihydroxysucci (R)-4-(2-(tert-Butylamino)-1-hydroxyethyl)-2-(hydroxy-methyl)phenol (2R,3R)-2,3-dihydroxysuccinat |
| CAS | 661464-94-4 |
| InChI | InChI=1/C13H21NO3.C6H10O4/c1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-3(5(7)8)4(2)6(9)10/h4-6,12,14-17H,7-8H2,1-3H3;3-4H,1-2H3,(H,7,8)(H,9,10)/t12-;3-,4-/m01/s1 |
Xopenex HFA - Physico-chemical Properties
| Molecular Formula | C17H27NO9 |
| Molar Mass | 389.39758 |
| Storage Condition | Room Temprature |
| In vivo study | In children with asthma, after 1 hour of continuous treatment with Racemic albuterol (3.75 mg, bid), compared with the administration of Levalbuterol (7.5 mg, bid), improved their forced expiratory volume in 1 second (FEV1) and asthma severity. The dramatic improvement in asthma symptoms was maintained after the second hour of continuous treatment in the racemic albuterol group, but the improvement in forced expiratory volume (FEV1) measurements within 1 second disappeared. In patients with asthma or chronic obstructive pulmonary disease (COPD), Levalbuterol (2.5 mg) requires significantly less mean total and predetermined aerosolized dose compared to racemic albuterol (1.25 mg). In the levalbuterol (1.25 mg) and racemic albuterol (2.5 mg) treatment groups, there was a significant increase from baseline in the disease symptom assessment and in the subject's general well-being score, the average score of β-mediated adverse reactions in the levalbuterol group was significantly higher than that in the racemic albuterol group. |
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